Best practices for developing iPad optimised web app?

I’d like to create simple iPad optimised ‘MVP’ web app.
But I am not sure exactly whether Rails would work nicely for me.
I’m quite familiar with css media queries and can take care of responsive UI just fine, but not sure if static pages would be a nice idea and if there are any gotchas?
Would you recommend any best practices for developing iPad web apps?
Or would something like backbone.js would be better for that?(i don’t know backbone at all for now, so that may be a problem).